MOLECULAR AND IMMUNOHISTOCHEMICAL EVALUATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR AND C-ERB-B-2 GENE-PRODUCT IN TRANSITIONAL-CELL CARCINOMAS OF THE URINARY-BLADDER - A STUDY IN GREEK PATIENTS

被引:0
作者
GORGOULIS, VG
BARBATIS, C
POULIAS, I
KARAMERIS, AM
机构
[1] RES CROSS HOSP,DEPT PATHOL & UROL,GR-11524 ATHENS,GREECE
[2] 401 ARMY GEN HOSP,DEPT PATHOL,ATHENS,GREECE
关键词
TRANSITIONAL CELL CARCINOMA; EGFR; C-ERB-B-2; DIFFERENTIAL PCR;
D O I
暂无
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
In this study, the expression of epidermal growth factor receptor (EGFr) and c-erb-B-2 was evaluated in 35 formalin-fixed, paraffin-embedded cases of transitional cell carcinomas of the urinary bladder (TCCs), EGFr and c-erb-B-2 expression was assessed with immunohistochemistry, and molecular analysis of the respective genes was performed with the differential polymerase chain reaction. The results were statistically analyzed in relationship to histologic grade, stage, and clinical outcome, Strong cytoplasmic expression of the EGFr using the polyclonal antibody Ab-4 was found in three (25%) Grade 2 and eight (67%) Grade 3 TCCs (P < 0.01). Two Grade 2 (17%) and 11 (92%) Grade 3 TCCs strongly expressed the anti-c-erb-B-2 Ab-3 antibody, None of Ta/T1 TCCs cases showed strong expression against EGFr, in contrast to c-erb-B-2 where two cases (18%) were found to express an intense immunosignal. Eleven (85%) T2/T3 cases showed strong positivity either against EGFr or c-erb-B-2 (P < 0.001). Eleven patients died within 12 months after the diagnosis, and all of them showed strong expression of EGFr and c-erb-B-2, Amplification of EGFr and c-erb-B-2 genes was identified in one (3%) and four (11%) TCCs cases, respectively, All patients with amplified genes died within 12 months from the date of diagnosis, Our results indicate that simultaneous expression of EGFr and c-erb-B-2 occurs in TCCs, is related to the histologic grade and the stage of the disease, and denotes aggressive biologic behavior.
引用
收藏
页码:758 / 764
页数:7
相关论文
共 50 条
[1]   THE PRODUCT OF THE HUMAN C-ERBB-2 GENE - A 185-KILODALTON GLYCOPROTEIN WITH TYROSINE KINASE-ACTIVITY [J].
AKIYAMA, T ;
SUDO, C ;
OGAWARA, H ;
TOYOSHIMA, K ;
YAMAMOTO, T .
SCIENCE, 1986, 232 (4758) :1644-1646
[2]  
ASAMOTO M, 1990, ACTA PATHOL JAPON, V40, P322
[3]   INCREASED TYROSINE KINASE-ACTIVITY ASSOCIATED WITH THE PROTEIN ENCODED BY THE ACTIVATED NEU ONCOGENE [J].
BARGMANN, CI ;
WEINBERG, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (15) :5394-5398
[4]   EVALUATION OF EPIDERMAL GROWTH-FACTOR RECEPTORS IN BLADDER-TUMORS [J].
BERGER, MS ;
GREENFIELD, C ;
GULLICK, WJ ;
HALEY, J ;
DOWNWARD, J ;
NEAL, DE ;
HARRIS, AL ;
WATERFIELD, MD .
BRITISH JOURNAL OF CANCER, 1987, 56 (05) :533-537
[5]   TRANSMEMBRANE TGF-ALPHA PRECURSORS ACTIVATE EGF TGF-ALPHA RECEPTORS [J].
BRACHMANN, R ;
LINDQUIST, PB ;
NAGASHIMA, M ;
KOHR, W ;
LIPARI, T ;
NAPIER, M ;
DERYNCK, R .
CELL, 1989, 56 (04) :691-700
[6]  
COOMBS L, 1989, UROL RES, V17, P345
[7]   AMPLIFICATION AND OVER-EXPRESSION OF C-ERBB-2 IN TRANSITIONAL CELL-CARCINOMA OF THE URINARY-BLADDER [J].
COOMBS, LM ;
PIGOTT, DA ;
SWEENEY, E ;
PROCTOR, AJ ;
EYDMANN, ME ;
PARKINSON, C ;
KNOWLES, MA .
BRITISH JOURNAL OF CANCER, 1991, 63 (04) :601-608
[8]   IMMUNOCYTOCHEMICAL LOCALIZATION OF C-ERBB-2 PROTEIN IN TRANSITIONAL CELL-CARCINOMA OF THE URINARY-BLADDER [J].
COOMBS, LM ;
OLIVER, S ;
SWEENEY, E ;
KNOWLES, M .
JOURNAL OF PATHOLOGY, 1993, 169 (01) :35-42
[9]   GENETIC ALTERATIONS IN BLADDER-CANCER [J].
DALBAGNI, G ;
PRESTI, J ;
REUTER, V ;
FAIR, WR ;
CORDONCARDO, C .
LANCET, 1993, 342 (8869) :469-471
[10]  
DAMJANOV I, 1986, LAB INVEST, V55, P588