DETERMINATION OF THIOL-CONTAINING DRUGS BY CHEMILUMINESCENCE FLOW-INJECTION ANALYSIS

被引：44
作者：
VINAS, P
GARCIA, IL
GIL, JAM
机构：
[1] Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 01期
关键词：
CHEMILUMINESCENCE; FLOW INJECTION ANALYSIS; CYSTEINE; N-ACETYLCYSTEINE; PENICILLAMINE; 2-MERCAPTOPROPIONYLGLYCINE; THIOURACIL;
D O I：
10.1016/0731-7085(93)80144-P
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A flow injection analysis procedure with chemiluminescence detection for the determination of both thiol-containing drugs and the amino acid cysteine is described. Procedures are based on the inhibition by the drugs of the chemiluminescence generated in the copper-catalysed oxidation of luminol by hydrogen peroxide. The proposed methods were applied to the determination of cysteine, N-acetylcysteine, penicillamine, 2-mercaptopropionylglycine and thiouracil in pharmaceuticals.
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页码：15 / 20
页数：6
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