PSEUDOMONAS-AERUGINOSA BIOFILM AS A DIFFUSION BARRIER TO PIPERACILLIN

被引：117

作者：

HOYLE, BD

ALCANTARA, J

COSTERTON, JW

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 09期

关键词：

D O I：

10.1128/AAC.36.9.2054

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2 . 2H2O prevented diffusion. Biofilms permitted equilibration of [C-14]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca2+-treated P. aeruginosa 579 biofilms and fluids distal to a viable P. aeruginosa mutant noninducible for the expression of beta-lactamase did not detect piperacillinoic acid.

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页码：2054 / 2056

页数：3

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