MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY OF AMOXICILLIN AND RELATED MOLECULES

被引：17

作者：

OKAFO, GN ^{[1
]}

CAMILLERI, P ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,THE FRYTHE,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

来源：

ANALYST | 1992年 / 117卷 / 09期

关键词：

MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY; ANTIBIOTIC; AUGMENTIN; DEUTERIUM OXIDE;

D O I：

10.1039/an9921701421

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A micellar electrokinetic capillary chromatographic method has been developed for the qualitative assay of amoxycillin and its degradation products and clavulanic acid. Together with amoxycillin the latter acid is an important constituent in the antibiotic Augmentin. The analytical procedure is fast and analytes can be identified both from their migration times and from changes in migration time observed either at different pH values or in electropherograms run in H2O and D2O based buffers of the same acidity.

引用

页码：1421 / 1424

页数：4

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