A CYCLIC AMP-ACTIVATED K+ CHANNEL IN DROSOPHILA LARVAL MUSCLE IS PERSISTENTLY ACTIVATED IN DUNCE

被引：65

作者：

DELGADO, R ^{[1
]}

HIDALGO, P ^{[1
]}

DIAZ, F ^{[1
]}

LATORRE, R ^{[1
]}

LABARCA, P ^{[1
]}

机构：

[1] UNIV CHILE,FAC CIENCIAS,DEPT BIOL,SANTIAGO,CHILE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 02期

关键词：

D O I：

10.1073/pnas.88.2.557

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.

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页码：557 / 560

页数：4

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