COADMINISTRATION OF (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID AND ARACHIDONIC-ACID POTENTIATES SYNAPTIC TRANSMISSION IN RAT HIPPOCAMPAL SLICES

被引：30
作者：
COLLINS, DR [1 ]
DAVIES, SN [1 ]
机构：
[1] UNIV ABERDEEN MARISCHAL COLL,DEPT BIOMED SCI,ABERDEEN AB9 1AS,SCOTLAND
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 240卷 / 2-3期
关键词：
LONG-TERM POTENTIATION; ARACHIDONIC ACID; METABOTROPIC RECEPTOR;
D O I：
10.1016/0014-2999(93)90919-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Perfusion of the 1S,3R isomer of trans-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD, 50 muM), or arachidonic acid (10 muM), for 5 min produced only depression of the field excitatory postsynaptic potential recorded in the CA1 region of rat hippocampal slices from which the CA3 region had been removed. However, perfusion of t-ACPD and arachidonic acid in combination induced a rapid potentiation of the response which in 4/6 slices was maintained for at least 90 min.
引用
收藏
页码：325 / 326
页数：2
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