THE STRUCTURE AND EXPRESSION OF THE GUINEA-PIG FC-RECEPTOR FOR IGG1 AND IGG2 (FC-GAMMA-1-GAMMA-2R)

被引：10
作者：
TOMINAGA, M
SAKATA, A
OHMURA, T
YAMASHITA, T
KOYAMA, J
ONOUE, K
机构：
[1] KUMAMOTO UNIV,COLL MED SCI,KUMAMOTO 862,JAPAN
[2] HOKKAIDO UNIV,FAC PHARMACEUT SCI,DEPT HYG CHEM,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)92375-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A cDNA clone encoding the receptor for guinea pig immunoglobulin G was isolated from a guinea pig peritoneal macrophage cDNA library. The cloned cDNA encoded 271 amino acids containing an N-terminal signal sequence. The deduced amino acid sequence is most homologous to murine FcγRIIß2. The receptor protein could be expressed in COS-7 and L cells transfected with the cDNA, suggesting that the expression of this receptor does not require the co-expression of a second chain such as γ chain of Fcε{lunate}RI or CD3ζ chain. The transformant L cells showed the binding to both the guinea pig IgG1 and IgG2 antibodies complexed with antigen, indicating that the cDNA we cloned was the one for guinea pig Fcγ1> γ2R. © 1990.
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页码：683 / 689
页数：7
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