Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects

Background: Obesity is a major risk factor for developing cardiovascular disorders due to increased platelets count and platelets activation. Objective: The aim of this study was to measure the influence of weight loss on the coagulation and fibrinolysis parameters among obese patients. Material and Methods: One hundred obese subjects of both genders (mean age 46.72+/-3.13 year) selected from the Internal Medicine Department at King Abdul Aziz University Teaching Hospital, their body mass index (BMI) ranged from 32 to 36 Kg/m(2). Participants enrolled randomly into two study groups; the first group (A) received aerobic exercises and diet regimen for three months, while the second group (B) received no exercise training or diet regimen for three months. Results: Mean values of von Willbrand factor antigen (vWF-Ag), fibrinogen, plasminogen activator inhibitor-1 antigen (PAI-1:Ag) and plasminogen activator inhibitor-1 activity (PAI-1:Ac), tumor necrotic factor-alpha (TNF-alpha), Interleukin - 6 (IL-6) and body mass index (BMI), while the mean values of partial thromboplastin time (PTT), prothrombin time (PT), tissue plasminogen activator antigen (tPA:Ag) and tissue plasminogen activator activity (tPA: Ac) increased significantly after 3 months in group (A) as a result of weight reduction program. However, the mean values of all investigated parameters of group (B) had no significant changes. Moreover, comparison between both groups had statistical significant differences in all investigated parameters at the end of the study (P<.05). Conclusion: weight reduction program modulates systemic inflammation, fibrinolytic and coagulation of obese subjects.