IGG SUBCLASSES IN COLLAGEN-INDUCED ARTHRITIS IN THE RAT

被引：20

作者：

FIRTH, SA

MORGAN, K

EVANS, HB

HOLT, PJL

机构：

[1] Department of Rheumatology, University of Manchester Medical School, Manchester, M13 9PT, Oxford Road

来源：

IMMUNOLOGY LETTERS | 1984年 / 7卷 / 05期

关键词：

arthritis; collagen-induced; IgG; rat; subclass;

D O I：

10.1016/0165-2478(84)90029-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using a solid-phase double-antibody radioimunoassay IgG antibodies to native bovine type II collagen were measured as total IgG and as subclasses of IgG (IgG1, IgG2a, IgG2b, IgG2c) in arthritic and non-arthritic Sprague-Dawley rats. Statistically significant differences were observed between arthritic and non-arthritic animals for IgG1, IgG2a, IgG2b and total IgG. The significance of these results and their possible relevance to the human disease are discussed. © 1984.

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页码：243 / 247

页数：5

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