Ductal Carcinoma In Situ: What the Pathologist Needs to Know and Why

被引：28

作者：

Bane, Anita ^{[1
,2
]}

机构：

[1] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON L8V 1C3, Canada

[2] McMaster Univ, Dept Oncol, Hamilton, ON L8V 1C3, Canada

来源：

INTERNATIONAL JOURNAL OF BREAST CANCER | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/914053

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ductal carcinoma in situ is a proliferation of malignant epithelial cells confined to the ductolobular system of the breast. It is considered a pre-cursor lesion for invasive breast cancer and when identified patients are treated with some combination of surgery, +/- radiation therapy, and +/adjuvant tamoxifen. However, no good biomarkers exist that can predict with accuracy those cases of DCIS destined to progress to invasive disease or once treated those patients that are likely to suffer a recurrence; thus, in the era of screening mammography it seems likely that many patients with DCIS are overtreated. This paper details the parameters that should be included in a pathology report for a case of DClS with some explanations as to their importance for good clinical decision making.

引用

页数：7

共 53 条

[1] Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: Further evidence to support the concept of low nuclear grade breast neoplasia family [J].

Abdel-Fatah, Tarek M. A. ;

Powe, Desmond G. ;

Hodi, Zsolt ;

Reis-Filho, Jorge S. ;

Lee, Andrew H. S. ;

Ellis, Ian O. .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2008, 32 (04) :513-523

[2] Ductal carcinoma in situ with microinvasion [J].

Adamovich, TL ;

Simmons, RM .

AMERICAN JOURNAL OF SURGERY, 2003, 186 (02) :112-116

[3] Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution [J].

Allred, D. Craig ;

Wu, Yun ;

Mao, Sufeng ;

Nagtegaal, Iris D. ;

Lee, Sangjun ;

Perou, Charles M. ;

Mohsin, Syed K. ;

O'Connell, Peter ;

Tsimelzon, Anna ;

Medina, Dan .

CLINICAL CANCER RESEARCH, 2008, 14 (02) :370-378

[4] Adjuvant Tamoxifen Reduces Subsequent Breast Cancer in Women With Estrogen Receptor-Positive Ductal Carcinoma in Situ: A Study Based on NSABP Protocol B-24 [J].

Allred, D. Craig ;

Anderson, Stewart J. ;

Paik, Soonmyung ;

Wickerham, D. Lawrence ;

Nagtegaal, Iris D. ;

Swain, Sandra M. ;

Mamounas, Elefetherios P. ;

Julian, Thomas B. ;

Geyer, Charles E., Jr. ;

Costantino, Joseph P. ;

Land, Stephanie R. ;

Wolmark, Norman .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (12) :1268-1273

[5] NONINVASIVE DUCTAL CARCINOMA OF THE BREAST - THE RELEVANCE OF HISTOLOGIC CATEGORIZATION [J].

BELLAMY, COC ;

MCDONALD, C ;

SALTER, DM ;

CHETTY, U ;

ANDERSON, TJ .

HUMAN PATHOLOGY, 1993, 24 (01) :16-23

[6] Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: Ten-Year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853 - A study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group [J].

Bijker, Nina ;

Meijnen, Philip ;

Peterse, Johannes L. ;

Bogaerts, Jan ;

Van Hoorebeeck, Irene ;

Julien, Jean-Pierre ;

Gennaro, Massimiliano ;

Rouanet, Philippe ;

Avril, Antoine ;

Fentiman, Ian S. ;

Bartelink, Harry ;

Rutgers, Emiel J. Th. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (21) :3381-3387

[7] Breast Cancer: Noninvasive and Special Situations [J].

Carlson, Robert W. ;

Allred, D. Craig ;

Anderson, Benjamin O. ;

Burstein, Harold J. ;

Carter, W. Bradford ;

Edge, Stephen B. ;

Erban, John K. ;

Farrar, William B. ;

Forero, Andres ;

Giordano, Sharon Hermes ;

Goldstein, Lori J. ;

Gradishar, William J. ;

Hayes, Daniel F. ;

Hudis, Clifford A. ;

Ljung, Britt-Marie ;

Marcom, P. Kelly ;

Mayer, Ingrid A. ;

McCormick, Beryl ;

Pierce, Lori J. ;

Reed, Elizabeth C. ;

Smith, Mary Lou ;

Som, George ;

Topham, Neal S. ;

Ward, John H. ;

Winer, Eric P. ;

Wolff, Antonio C. .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2010, 8 (10) :1182-1207

[8] Molecular subtyping of DCIS: heterogeneity of breast cancer reflected in pre-invasive disease [J].

Clark, S. E. ;

Warwick, J. ;

Carpenter, R. ;

Bowen, R. L. ;

Duffy, S. W. ;

Jones, J. L. .

BRITISH JOURNAL OF CANCER, 2011, 104 (01) :120-127

[9] Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy - Results from the Nurses' Health Study [J].

Collins, LC ;

Tamimi, RM ;

Baer, HJ ;

Connolly, JL ;

Colditz, GA ;

Schnitt, SJ .

CANCER, 2005, 103 (09) :1778-1784

[10] Breast ductal carcinoma in situ with microinvasion -: A definition supported by a long-term study of 1248 serially sectioned ductal carcinomas [J].

de Mascarel, I ;

MacGrogan, G ;

Mathoulin-Pélissier, S ;

Soubeyran, I ;

Picot, V ;

Coindre, JM .

CANCER, 2002, 94 (08) :2134-2142

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