The future role of gut hormones in the treatment of obesity

被引：82

作者：

Troke, Rachel C. ^{[1
]}

Tan, Tricia M. ^{[1
]}

Bloom, Steve R. ^{[1
]}

机构：

[1] Imperial Coll London, Dept Investigat Med, Div Diabet Endocrinol & Metab, 6th Floor,Commonwealth Bldg, London W12 0HS, England

来源：

THERAPEUTIC ADVANCES IN CHRONIC DISEASE | 2014年 / 5卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

GLP-1; obesity; oxyntomodulin; peptide YY; therapeutic;

D O I：

10.1177/2040622313506730

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The obesity pandemic presents a significant burden, both in terms of healthcare and economic outcomes, and current medical therapies are inadequate to deal with this challenge. Bariatric surgery is currently the only therapy available for obesity which results in long-term, sustained weight loss. The favourable effects of this surgery are thought, at least in part, to be mediated via the changes of gut hormones such as GLP-1, PYY, PP and oxyntomodulin seen following the procedure. These hormones have subsequently become attractive novel targets for the development of obesity therapies. Here, we review the development of these gut peptides as current and emerging therapies in the treatment of obesity.

引用

页码：4 / 14

页数：11

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