Vaccination in Chronic Renal Failure Patients

Patients with chronic kidney disease are immunocompromised and are at high risk for several infections. Renal patients present impaired cell-mediated and humoral immunity, reducing activities of the immune system cells leading to a lower seroconversion rate, a lower peak of antibody titers and a quicker decline of antibody levels in these patients as compared with healthy subjects. Thus, usual schedules of vaccination may be ineffective so after the routine programmes the antibody titres should be measured and a booster dose should be given when necessary.