GENOTOXICITY IN OXAZOLIDINE DERIVATIVES - INFLUENCE OF THE NITRO-GROUP

被引：40

作者：

VANELLE, P

DEMEO, MP

MALDONADO, J

NOUGUIER, R

CROZET, MP

LAGET, M

DUMENIL, G

机构：

[1] FAC PHARM MARSEILLE,CHIM ORGAN LAB,27 BD JEAN MOULIN,F-13385 MARSEILLE 5,FRANCE

[2] FAC PHARM MARSEILLE,MICROBIOL LAB,F-13385 MARSEILLE 5,FRANCE

[3] FAC ST JEROME MARSEILLE,CHIM ORGAN LAB B,CNRS,URA 109,F-13397 MARSEILLE 13,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 03期

关键词：

aldehyde; genotoxicity; nitro groups; oxazolidine; TRIS;

D O I：

10.1016/0223-5234(90)90207-J

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tris-(hydroxymethyl)-aminomethane reacts with various aromatic or heterocyclic aldehydes, leading to new mono- or bicyclic oxazolidine derivatives. The importance of molecular surroundings of the nitro group has been evaluated by the genotoxic study of synthetised compounds using metronidazole and dimetridazole as reference compounds. © 1990.

引用

页码：241 / 250

页数：10

共 21 条

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