SCANNING AND TRANSMISSION ELECTRON-MICROSCOPIC ANALYSIS OF RAT PLATELETS ADHERED TO MICRODOMAIN STRUCTURED SURFACE OF 2-HYDROXYETHYL METHACRYLATE STYRENE ABA TYPE BLOCK COPOLYMER

被引：1

作者：

ABE, K

SEKIGUCHI, M

OKANO, T

KATAOKA, K

SAKURAI, Y

SHIMADA, M

SHINOHARA, I

机构：

[1] Tokyo Women's Medical Coll, Tokyo, Jpn, Tokyo Women's Medical Coll, Tokyo, Jpn

来源：

KOBUNSHI RONBUNSHU | 1988年 / 45卷 / 06期

关键词：

BLOCK COPOLYMERS - Surfaces - MICROSCOPES; ELECTRON; -; POLYSTYRENES;

D O I：

10.1295/koron.45.511

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In order to clarify the antithrombogenic mechanism of 2-hydroxyethyl methacrylate-styrene ABA type block copolymer which has microdomain-structured surfaces, shape and cytological changes of rat platelets adhered to the polymer surfaces in vitro were analyzed by scanning and transmission electron microscopy. Poly(2-hydroxyethyl methacrylate) and polystyrene with homogeneous surfaces were used for control polymers. Platelets which adhered to the homogeneous surfaces underwent aggregation and cytological changes such as release of alpha-granules and dense bodies as well as extensions of the open canalicular system. On the other hand, platelets which adhered to the microdomain-structured surfaces were round, and were observed to retain organella such as alpha-granules and mitochondria.

引用

页码：511 / 517

页数：7