THE INFLUENCE OF POLYHEXAMETHYLENEGUANIDIN ON POLYAMINE METABOLISM IN MONGREL RATS AND ON THE GROWTH AND METASTATIC SPREADING OF TRANSPLANTABLE LEWIS LUNG-CARCINOMA IN C57B1 MICE

被引：0

作者：

ZALETOK, SP ^{[1
]}

LYALYUSHKO, NM ^{[1
]}

BERDINSKIKH, NK ^{[1
]}

IGNATENKO, NA ^{[1
]}

LIDAK, MY ^{[1
]}

BAUMANIS, EA ^{[1
]}

BIRSKA, IA ^{[1
]}

机构：

[1] LATVIAN ACAD SCI,INST ORGAN SYNTH,RIGA 1067,LATVIA

来源：

EKSPERIMENTALNAYA ONKOLOGIYA | 1993年 / 15卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polyhexamethyleneguanidin (PMG) has been studied for its effect on some indices of polyamine metabolism in mongrel rats after preliminary induction of ornithi ne decarboxylase (ODC) activity in kidneys by means of testosterone. It has been found that PMG influences the synthesis of polyamines and inhibits activity of ODC, a key enzyme of their synthesis, which causes a decrease of the polyamines content in the target organ and in biological fluids of the organism (blood and urine). The effect of PMG on the growth and metastatic spreading of the Lewis lung carcinoma was studied in C57B1 mice. It has been shown that antitumour and antimetastatic effect of PMG depends on the dose, the number of injections and the terms of the drug administration. Combined administration of ceruloplasmin and PMG reduces the toxic effect of the latter and intensifies the antitumour and antimetastatic effects, which evidences for the expediency of combined application of PMG and ceruloplasmin.

引用

页码：36 / 40

页数：5

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