LOVASTATIN INDUCES GROWTH-INHIBITION AND APOPTOSIS IN HUMAN-MALIGNANT GLIOMA-CELLS

被引：166
作者：
JONES, KD
COULDWELL, WT
HINTON, DR
SU, YH
HE, SK
ANKER, L
LAW, RE
机构：
[1] UNIV SO CALIF,SCH MED,DEPT NEUROL SURG,LOS ANGELES,CA 90033
[2] UNIV SO CALIF,SCH MED,DEPT PATHOL,LOS ANGELES,CA 90033
[3] UNIV SO CALIF,SCH MED,DEPT MED,DIV ENDOCRINOL DIABET & HYPERTENS,LOS ANGELES,CA 90033
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 03期
关键词：
D O I：
10.1006/bbrc.1994.2861
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The competitive HMG-CoA reductase inhibitor lovastatin has been shown to suppress growth and induce morphological changes in a variety of non-glioma tumor cell lines. This study assesses the effects of this agent on the growth and survival of the human malignant glioma cell lines A172 and U87-MG. The response to the drug was investigated using a cell proliferation assay which revealed significant dose-dependent growth inhibition. Treatment with as little as 100 nM lovastatin over a period of 72 hours led to DNA degradation into nucleosome-sized fragments characteristic of apoptosis. Our data suggest that HMG-CoA reductase inhibitors such as lovastatin merit further investigation as potential therapeutic agents for the treatment of malignant gliomas. (C) 1994 Academic Press, Inc.
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页码：1681 / 1687
页数：7
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