MECHANISMS OF GLYCATION IN ATHEROGENESIS

被引：11

作者：

PAMPLONA, R ^{[1
]}

BELLMUNT, MJ ^{[1
]}

PORTERO, M ^{[1
]}

PRAT, J ^{[1
]}

机构：

[1] UNIV LLEIDA, FAC MED,DPT CIENCIES MED BASIQUES, RECERCA FISIOPATOL METAB GRP,C-ROVIRA ROURE 44, E-25006 LLEIDA, SPAIN

来源：

MEDICAL HYPOTHESES | 1993年 / 40卷 / 03期

关键词：

D O I：

10.1016/0306-9877(93)90207-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Non-enzymatic glycation may affect the arterial wall altering its connective tissue and promoting LDL accumulation. Its recognition by specific receptors and growth factor release, as well as possible alteration of DNA, may stimulate smooth muscle cell proliferation. Free radical generation may favour non-enzymatic PUFA degradation and quench NO, which would alter vascular relaxation. All of these aspects may participate in atherogenesis.

引用

页码：174 / 181

页数：8

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