SYNTHESIS, SPECTROSCOPIC, THERMAL STUDIES AND BIOLOGICAL ACTIVITY OF A NEW SULFAMETHOXAZOLE SCHIFF BASE AND ITS COPPER COMPLEXES

被引：12

作者：

El-Nawawy, M. A. ^{[1
]}

Farag, R. S. ^{[1
]}

Sabbah, I. A. ^{[1
]}

Abu-Yamin, A. M. ^{[1
]}

机构：

[1] Al Azhar Univ, Fac Sci, Dept Chem, Cairo, Egypt

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2011年 / 2卷 / 12期

关键词：

Sulfamethoxazole; Schiff base; Copper complex; Antibacterial and Antifungal activities;

D O I：

10.13040/IJPSR.0975-8232.2(12).3143-48

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new Sulfamethoxazole Schiff base (E)-4-(4-methoxybenzylideneamino)-N-(5- methylis-oxazol-3-yl) benzenesulfonamide (C18H17N3O4S), and its copper complex were synthesized and the structures elucidated on the basis of Physiochemical methods. The studies indicate an octahedral structure for the complexes with the (C22H27N3O10SCu) formula. The IR spectra suggest that the ligand act as tridentate (from oxygen and two nitrogen atoms) donor. Also the biological activity of the Schiff base and its Cu complex were studied.

引用

收藏

页码：3143 / 3148

页数：6

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