ROLE OF PROPHYLACTIC ANTIBIOTICS IN OPEN AND BASILAR FRACTURES OF THE SKULL - A RANDOMIZED STUDY

被引：23

作者：

DEMETRIADES, D

CHARALAMBIDES, D

LAKHOO, M

PANTANOWITZ, D

机构：

[1] Baragwanath Hospital, the University of the Witwatersrand, Johannesburg

来源：

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 1992年 / 23卷 / 06期

关键词：

D O I：

10.1016/0020-1383(92)90011-G

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The aim of this study was to investigate the controversial issue of the use of prophylactic antibiotics in open and basilar fractures of the skull. A series of 157 patients were randomized to receive no antibiotics (group A = 46 patients) or ceftriaxone for 3 days (group B = 50 patients), or the combination ampicillin/sulphadiazine for 3 days (group C = 61 patients). The incident of meningitis was similar in both the antibiotic and non-antibiotic groups. However, the overall incident of infectious complications in the non-antibiotic group was significantly higher than in the antibiotic group (8.7 per cent vs 0.9 per cent, P < 0.05). There was no significant difference between the ceftriaxone group and the ampicillin/sulphadiazine group The results of the study suggest that antibiotic prophylaxis has a role in the management of open and basilar fractures.

引用

页码：377 / 380

页数：4

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