ASSAY FOR GENE MUTATION IN A HUMAN LYMPHOBLAST LINE, AHH-1, COMPETENT FOR XENOBIOTIC METABOLISM

被引：116

作者：

CRESPI, CL ^{[1
]}

THILLY, WG ^{[1
]}

机构：

[1] MIT, TOXICOL GRP, CAMBRIDGE, MA 02139 USA

来源：

MUTATION RESEARCH | 1984年 / 128卷 / 02期

关键词：

D O I：

10.1016/0027-5107(84)90110-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A novel quantitative gene-locus mutation assay was developed using a line of human lymphoblast cells, designated AHH-1, competent in oxidative xenobiotic metabolism. AHH-1 cells are sensitive to the mutagenic action of both chemically reactive mutagens and mutagens which require oxidative metabolism to exert their mutagenicity. These cells are readily mutated by direct exposure to ethyl methanesulfonate, ICR-191, 2-acetoaminofluorene, aflatoxin B1, benzo[a]pyrene (BP), cytopenta[c,d]pyrene dimethylnitrosamine, lasiocarpine and 1-methylphenanthrene.

引用

页码：221 / 230

页数：10

共 25 条

[1]

Barfknecht T., 1981, Chemical Analysis and Biological Fate: Polynuclear Aromatic Hydrocarbons, P231

[2] ULTRAVIOLET LIGHT-INDUCED MUTATION OF DIPLOID HUMAN-LYMPHOBLASTS [J].