ISOLATION OF EQUINE HERPESVIRUS-1 MUTANTS IN THE PRESENCE OF (S)-9-(3-HYDROXY-2-PHOSPHONYLMETHOXYPROPYL)ADENINE - DEMONSTRATION OF RESISTANCE INVITRO AND INVIVO

被引：7
作者：
FIELD, HJ
AWAN, AR
DELAFUENTE, R
机构：
[1] Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge
来源：
ANTIVIRAL RESEARCH | 1991年 / 16卷 / 01期
关键词：
EQUINE HERPESVIRUS-1; EHV-1; RESISTANCE; PHOPHONYL; NUCLEOSIDE ANALOG; CHEMOTHERAPY;
D O I：
10.1016/0166-3542(91)90056-W
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The compound (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) had been previously shown to be highly effective in treatment of EHV-1 in a murine model for the equine disease. This paper describes the isolation of a series of mutants resistant to the drug. Resistance was demonstrated in cell culture and one mutant was tested in a murine model. The resistant mutant was pathogenic for mice; infectious virus was recovered from respiratory tissues and blood at levels similar to the parental virus. However, the mutant showed a significant degree of resistance in vivo, thus proving the virus-specific mode of action of the antiviral compound.
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页码：29 / 39
页数：11
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