THERAPEUTIC POTENTIAL OF CAPSAICIN-LIKE MOLECULES - TREATMENT PARAMETERS OF DESENSITIZATION TO CAPSAICIN

被引：40
作者：
CRAFT, RM
PORRECA, F
机构：
[1] Department of Pharmacology University, Arizona Health Sciences Center Tucson
来源：
LIFE SCIENCES | 1992年 / 51卷 / 23期
关键词：
D O I：
10.1016/0024-3205(92)90046-R
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Desensitization of sensory afferents with topical capsaicin has been employed to treat a variety of neuropathic disorders in humans, however, few studies have been undertaken to systematically evaluate treatment parameters to determine the optimal dose and frequency of treatment needed to achieve and maintain desensitization. The effects of several treatment parameters, including dose, number of exposures, interval between exposures and duration of exposure, on the development, magnitude and duration of desensitization following local treatment with capsaicin and related compounds are described.
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页码：1767 / 1775
页数：9
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