Effects of polyunsaturated fatty acids (omega-3) on the platelet aggregation

There is evidence that fish consumption containing Omega-3, offers cardiovascular protection. The American Heart Association (AHA) recommends to consume 1 g/day Omega-3 to reduce the risk of cardiovascular events. Eicosapentanoic and docosahexanoic acids have a chemical structure similar to araquidonic acid; it is supposed that they join the platelet membrane, competing with araquidonic acid as cyclooxygenase substrate, reducing platelet aggregation. This prospective-longitudinal study, with a sample of 30 selected individuals, was carried out knowing the turnover of the thrombocyte. it was intended to evaluate the effect of Omega-3 fatty acids on platelet aggregation, in vitro, over a 7-days period of treatment. Turbimetric method of Born using ADP, Collagen and epinephrine was used. A significantly statistical decrease on the platelet aggregation of 14.3 +/- 3.5% for ADP, 8.78 +/- 2.83% for Collagen and 10.87 +/- 3.11% for epinephrine was observed. In conclusion, 1 g of Omega-3 fatty acids taken daily diminishes, in a 7-days treatment, platelet aggregation, dependent on ADP, Collagen and epinephrine. It is a safe medication with no significant adverse events.