Current Issues and Clinical Evidence in Tumor-Infiltrating Lymphocytes in Breast Cancer

被引：36

作者：

Ahn, Sung Gwe ^{[1
]}

Jeong, Joon ^{[1
]}

Hong, Soon Won ^{[2
]}

Jung, Woo Hee ^{[2
]}

机构：

[1] Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Surg, 211 Eonju Ro, Seoul 06273, South Korea

[2] Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Pathol, Seoul 06273, South Korea

来源：

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE | 2015年 / 49卷 / 05期

关键词：

Breast neopalsms; Immune system; Lymphocytes; tumor-infiltrating; Triple negative breast neoplasms;

D O I：

10.4132/jptm.2015.07.29

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

With the advance in personalized therapeutic strategies in patients with breast cancer, there is an increasing need for biomarker-guided therapy. Although the immunogenicity of breast cancer has not been strongly considered in research or practice, tumor-infiltrating lymphocytes (TILs) are emerging as biomarkers mediating tumor response to treatments. Earlier studies have provided evidence that the level of TILs has prognostic value and the potential for predictive value, particularly in triple-negative and human epidermal growth factor receptor 2-positive breast cancer. Moreover, the level of TILs has been associated with treatment outcome in patients undergoing neoadjuvant chemotherapy. To date, no standardized methodology for measuring TILs has been established. In this article, we review current issues and clinical evidence for the use of TILs in breast cancer.

引用

页码：355 / 363

页数：9

共 60 条

[1] Regulatory T cells: recommendations to simplify the nomenclature [J].

Abbas, Abul K. ;

Benoist, Christophe ;

Bluestone, Jeffrey A. ;

Campbell, Daniel J. ;

Ghosh, Sankar ;

Hori, Shohei ;

Jiang, Shuiping ;

Kuchroo, Vijay K. ;

Mathis, Diane ;

Roncarolo, Maria Grazia ;

Rudensky, Alexander ;

Sakaguchi, Shimon ;

Shevach, Ethan M. ;

Vignali, Dario A. A. ;

Ziegler, Steve F. .

NATURE IMMUNOLOGY, 2013, 14 (04) :307-308

[2] Prognostic Value of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancers From Two Phase III Randomized Adjuvant Breast Cancer Trials: ECOG 2197 and ECOG 1199 [J].

Adams, Sylvia ;

Gray, Robert J. ;

Demaria, Sandra ;

Goldstein, Lori ;

Perez, Edith A. ;

Shulman, Lawrence N. ;

Martino, Silvana ;

Wang, Molin ;

Jones, Vicky E. ;

Saphner, Thomas J. ;

Wolff, Antonio C. ;

Wood, William C. ;

Davidson, Nancy E. ;

Sledge, George W. ;

Sparano, Joseph A. ;

Badve, Sunil S. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) :2959-+

[3] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[4] Association between CD8+T-cell infiltration and breast cancer survival in 12 439 patients [J].

Ali, H. R. ;

Provenzano, E. ;

Dawson, S-J ;

Blows, F. M. ;

Liu, B. ;

Shah, M. ;

Earl, H. M. ;

Poole, C. J. ;

Hiller, L. ;

Dunn, J. A. ;

Bowden, S. J. ;

Twelves, C. ;

Bartlett, J. M. S. ;

Mahmoud, S. M. A. ;

Rakha, E. ;

Ellis, I. O. ;

Liu, S. ;

Gao, D. ;

Nielsen, T. O. ;

Pharoah, P. D. P. ;

Caldas, C. .

ANNALS OF ONCOLOGY, 2014, 25 (08) :1536-1543

[5]

AN T, 1987, AM J PATHOL, V128, P52

[6] In breast cancer, a high ratio of tumour-infiltrating intraepithelial CD8+to FoxP3+cells is characteristic for the medullary subtype [J].

Anz, David ;

Eiber, Stephan ;

Scholz, Christoph ;

Endres, Stefan ;

Kirchner, Thomas ;

Bourquin, Carole ;

Mayr, Doris .

HISTOPATHOLOGY, 2011, 59 (05) :965-974

[7] Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse [J].

Bates, Gaynor J. ;

Fox, Stephen B. ;

Han, Cheng ;

Leek, Russell D. ;

Garcia, Jose F. ;

Harris, Adrian L. ;

Banham, Alison H. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (34) :5373-5380

[8] Metastatic triple-negative breast cancers at first relapse have fewer tumor-infiltrating lymphocytes than their matched primary breast tumors: a pilot study [J].

Cimino-Mathews, Ashley ;

Ye, Xiaobu ;

Meeker, Alan ;

Argani, Pedram ;

Emens, Leisha A. .

HUMAN PATHOLOGY, 2013, 44 (10) :2055-2063

[9] Leukocytes in Mammary Development and Cancer [J].

Coussens, Lisa M. ;

Pollard, Jeffrey W. .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2011, 3 (03) :1-22

[10] Presence of tumor-infiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer [J].

de Jong, R. A. ;

Leffers, N. ;

Boezen, H. M. ;

ten Hoor, K. A. ;

van der Zee, A. G. J. ;

Hollema, H. ;

Nijman, H. W. .

GYNECOLOGIC ONCOLOGY, 2009, 114 (01) :105-110

← 1 2 3 4 5 6 →