OXISURAN REDUCTION BY RABBIT TISSUE PREPARATIONS

被引：0
|
作者：
BACHUR, NR [1 ]
FELSTED, RL [1 ]
机构：
[1] NCI BALTIMORE CANC RES CTR, BIOCHEM SECT, BALTIMORE, MD 21211 USA
来源：
DRUG METABOLISM AND DISPOSITION | 1976年 / 4卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Oxisuran, 2-[(methylsulfinyl)acetyl]pyridine is reduced to .alpha.-[(methylsulfinyl)methyl]-2-pyridenimethanol, oxisuranol, by cytoplasmic enzymes from rabbit liver, kidney, brain, intestine and lung. The cytoplasmic enzyme from liver is dependent on NADPH as cofactor and has an optimal pH of 6.0. Enzymatic activity is also present in liver mitochondria but at a lower specific activity. The cytoplasmic extracts catalyze the formation of 2 oxisuranol products, presumably the diastereoisomers described by Di Carlo and associates from in vivo studies. Verification of the product as oxisuranol was accomplished by TLC and mass spectrometry.
引用
收藏
页码：239 / 243
页数：5
相关论文
共 50 条
  • [21] CHROMOSOME PREPARATIONS FROM RABBIT PREOVULATORY OOCYTES
    MORRISON, WD
    HUFF, V
    LITTLEFIELD, LG
    DUFRAIN, RJ
    MUTATION RESEARCH, 1983, 119 (02): : 169 - 175
  • [22] 2 PREPARATIONS FOR THE STUDY OF THE ISOLATED RABBIT OVIDUCT
    LEESE, HJ
    HUMPHERSON, PG
    JEFFRIES, KS
    JOURNAL OF REPRODUCTION AND FERTILITY, 1981, 63 (01): : 249 - 255
  • [23] MYOSIN PREPARATIONS FROM THE RABBIT, RAT AND MOUSE
    MILLER, GL
    GOLDER, RH
    EITELMAN, ES
    MILLER, EE
    FEDERATION PROCEEDINGS, 1952, 11 (01) : 260 - 260
  • [24] Aldehyde reduction in a novel pericardial tissue reduces calcification using rabbit intramuscular model
    Shang, Hao
    Claessens, Steven M.
    Tian, Bin
    Wright, Gregory A.
    JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2017, 28 (01)
  • [25] Aldehyde reduction in a novel pericardial tissue reduces calcification using rabbit intramuscular model
    Hao Shang
    Steven M. Claessens
    Bin Tian
    Gregory A. Wright
    Journal of Materials Science: Materials in Medicine, 2017, 28
  • [26] ENZYMATIC REDUCTION OF N-HYDROXY DERIVATIVES OF 2-ACETYLAMINOFLUORENE AND RELATED CARCINOGENS BY TISSUE PREPARATIONS
    LOTLIKAR, PD
    MILLER, EC
    MILLER, JA
    MARGRETH, A
    CANCER RESEARCH, 1965, 25 (10) : 1743 - &
  • [27] METABOLISM OF DAUNOMYCIN BY RAT TISSUE PREPARATIONS
    BACHUR, NR
    CRADOCK, JC
    GEE, M
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1970, 11 : 4 - &
  • [28] Detection and Reduction of Microaggregates in Insulin Preparations
    Heldt, Caryn L.
    Sorci, Mirco
    Posada, David
    Hirsa, Amir
    Belfort, Georges
    BIOTECHNOLOGY AND BIOENGINEERING, 2011, 108 (01) : 237 - 241
  • [29] PRAVADOLINE - PROFILE IN ISOLATED TISSUE PREPARATIONS
    WARD, SJ
    MASTRIANI, D
    CASIANO, F
    ARNOLD, R
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1990, 255 (03): : 1230 - 1239
  • [30] THE NATURE OF ENDOTHELIAL RELAXING FACTOR IN RABBIT AORTIC PREPARATIONS
    GRIFFITH, TM
    HENDERSON, AH
    EDWARDS, DH
    LEWIS, MJ
    NEWBY, AC
    JOURNAL OF PHYSIOLOGY-LONDON, 1983, 345 (DEC): : P171 - P171
12345