Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target

被引：239

作者：

Vidyasagar, Aparna ^{[1
]}

Wilson, Nancy A. ^{[1
]}

Djamali, Arjang ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Med, Nephrol Div, H4 564 CSC,600 Highland Ave, Madison, WI 53792 USA

来源：

FIBROGENESIS & TISSUE REPAIR | 2012年 / 5卷

关键词：

D O I：

10.1186/1755-1536-5-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles. The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target.

引用

页数：7

共 59 条

[41] Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis [J].

Martin-Ventura, JL ;

Duran, MC ;

Blanco-Colio, LM ;

Meilhac, O ;

Leclercq, A ;

Michel, JB ;

Jensen, ON ;

Hernandez-Merida, S ;

Tuñón, J ;

Vivanco, F ;

Egido, J .

CIRCULATION, 2004, 110 (15) :2216-2219

[42] Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFα in NIH-3T3-ras cells [J].

Mehlen, P ;

Hickey, E ;

Weber, LA ;

Arrigo, AP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 241 (01) :187-192

[43] HEAT SHOCK OF DROSOPHILA-MELANOGASTER INDUCES SYNTHESIS OF NEW MESSENGER-RNAS AND PROTEINS [J].

MORAN, L ;

MIRAULT, ME ;

ARRIGO, AP ;

GOLDSCHMIDTCLERMONT, M ;

TISSIERES, A .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1978, 283 (997) :391-406

[44] Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells [J].

Nakashima, Masanori ;

Adachi, Seiji ;

Yasuda, Ichiro ;

Yamauchi, Takahiro ;

Kawaguchi, Junji ;

Itani, Masahiko ;

Yoshioka, Takashi ;

Matsushima-Nishiwaki, Rie ;

Hirose, Yoshinobu ;

Kozawa, Osamu ;

Moriwaki, Hisataka .

CANCER LETTERS, 2011, 313 (02) :218-225

[45] Mechanisms of tubulointerstitial injury in the kidney: Final common pathways to end-stage renal failure [J].

Nangaku, M .

INTERNAL MEDICINE, 2004, 43 (01) :9-17

[46] Heat shock protein 27 controls apoptosis by regulating Akt activation [J].

Rane, MJ ;

Pan, Y ;

Singh, S ;

Powell, DW ;

Wu, R ;

Cummins, T ;

Chen, Q ;

McLeish, KR ;

Klein, JB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (30) :27828-27835

[47] Cyclosporine A induces vascular fibrosis and heat shock protein expression in rat [J].

Rezzani, R ;

Rodella, L ;

Buffoli, B ;

Giugno, L ;

Stacchiotti, A ;

Bianchi, R .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2005, 5 (01) :169-176

[48] Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress tumor necrosis factor α by phosphorylation [J].

Rogalla, T ;

Ehrnsperger, M ;

Preville, X ;

Kotlyarov, A ;

Lutsch, G ;

Ducasse, C ;

Paul, C ;

Wieske, M ;

Arrigo, AP ;

Buchner, J ;

Gaestel, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (27) :18947-18956

[49] Anti-heat shock protein-27 (Hsp-27) antibody levels in patients with chest pain: Association with established cardiovascular risk factors [J].

Shams, Sedigheh ;

Shafi, Shahida ;

Bodman-Smith, Kikki ;

Williams, Peter ;

Mehta, Sweta ;

Ferns, Gordon A. .

CLINICA CHIMICA ACTA, 2008, 395 (1-2) :42-46

[50] RENAL-CELL INJURY - METABOLIC AND STRUCTURAL ALTERATIONS [J].

SIEGEL, NJ ;

DEVARAJAN, P ;

VANWHY, S .

PEDIATRIC RESEARCH, 1994, 36 (02) :129-136

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