Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target

被引：239

作者：

Vidyasagar, Aparna ^{[1
]}

Wilson, Nancy A. ^{[1
]}

Djamali, Arjang ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Med, Nephrol Div, H4 564 CSC,600 Highland Ave, Madison, WI 53792 USA

来源：

FIBROGENESIS & TISSUE REPAIR | 2012年 / 5卷

关键词：

D O I：

10.1186/1755-1536-5-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles. The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target.

引用

页数：7

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