MULTISITE CLINICAL-TRIALS IN ALCOHOLISM-TREATMENT RESEARCH - ORGANIZATIONAL, METHODOLOGICAL AND MANAGEMENT ISSUES

被引：19
作者：
FULLER, RK
MATTSON, ME
ALLEN, JP
RANDALL, CL
ANTON, RF
BABOR, TF
机构：
来源：
JOURNAL OF STUDIES ON ALCOHOL | 1994年
关键词：
D O I：
10.15288/jsas.1994.s12.30
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Multisite clinical trials have two major advantages over single-site studies: the large sample size of multisite studies allows for adequate statistical power and better representativeness of the population being studied. However, they are more complex to implement than single-site studies. This article reviews previous multisite clinical trials of alcohol abuse and alcoholism, reasons for selecting a multisite design, management of such studies, and some statistical issues.
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页码：30 / 37
页数：8
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