MECHANISM OF ANTIOXIDANT PROTECTION OF RAT-LIVER AGAINST AROMATIC-AMINES

被引：0

作者：

LOMONOSOVA, EE

PIKULEV, AT

KURCHENKO, VP

机构：

来源：

BIOCHEMISTRY-MOSCOW | 1992年 / 57卷 / 07期

关键词：

LIPID PEROXIDATION; ANTIOXIDANT SYSTEM; AROMATIC AMINES;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of diaminodiphenyl, diphenylamine, and tetraaminodiphenyl on lipid peroxidation and the antioxidant protection mechanisms in subcellular fractions of rat liver cells were investigated Increased lipid peroxidation is important in the hepatotoxic effect of diaminodiphenyl and diphenylamine. This effect is due to a decrease in the protective action of the antioxidant system induced by intoxication with these aromatic amines. Tetraaminodiphenyl does not affect the rate of lipid peroxidation. Thus, differences in the structures of aromatic amines result in differences in the mechanisms of adaptation of the antioxidant system.

引用

页码：744 / 748

页数：5

共 18 条

[1]

AEBI H, 1984, METHOD ENZYMOL, V105, P121

[2]

Beauchamp C., 1971, ANAL BIOCHEM, V44, P276, DOI DOI 10.1016/0003-2697(71)90370-8

[3] ASSAYING FOR SUPEROXIDE-DISMUTASE ACTIVITY - SOME LARGE CONSEQUENCES OF MINOR CHANGES IN CONDITIONS [J].