RAPID SENSITIZATION TO THE CARDIOVASCULAR EFFECTS OF COCAINE IN RATS

被引：21
|
作者：
TELLA, SR
SCHINDLER, CW
GOLDBERG, SR
机构：
[1] GEORGETOWN UNIV,SCH MED,DEPT PHARMACOL,WASHINGTON,DC 20007
[2] UNIV MARYLAND,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 194卷 / 01期
关键词：
COCAINE; BLOOD PRESSURE; HEART RATE; SENSITIZATION; CARDIOVASCULAR TOXICITY; (RAT);
D O I：
10.1016/0014-2999(91)90133-B
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effects of repeated daily administrations of cocaine on blood pressure and heart rate were studied in conscious rats. Cocaine (0.03-3.0 mg/kg i.v.) increased blood pressure and heart rate the first time it was administered (day 1) However, the magnitude and duration of the increases in blood pressure caused by cocaine (0.1-3.0 mg/kg) dramatically increased on day 2 and remained (except 1.0 mg/kg dose) at these levels through day 5. Following two drug-free days (days 6 and 7), the increase in blood pressure caused by cocaine (0.1, 0.3 and 3.0 mg/kg) on day 8 was still elevated. Unlike blood pressure, no enhancement in heart rate response to cocaine was observed.
引用
收藏
页码：119 / 122
页数：4
相关论文
共 50 条
  • [1] Rapid and persistent sensitization to the reinforcing effects of cocaine
    Morgan, D
    Liu, Y
    Roberts, DCS
    NEUROPSYCHOPHARMACOLOGY, 2006, 31 (01) : 121 - 128
  • [2] Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine
    Drake Morgan
    Yu Liu
    David C S Roberts
    Neuropsychopharmacology, 2006, 31 : 121 - 128
  • [3] Effects of Gaboxadol on the Expression of Cocaine Sensitization in Rats
    Silverman, Nora Siegal
    Popp, Susanna
    Vialou, Vincent
    Astafurov, Konstantin
    Nestler, Eric J.
    Dow-Edwards, Diana
    EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2016, 24 (02) : 131 - 141
  • [4] Effects of sex and estrogen on behavioral sensitization to cocaine in rats
    Hu, M
    Becker, JB
    JOURNAL OF NEUROSCIENCE, 2003, 23 (02): : 693 - 699
  • [5] ACUTE CARDIOVASCULAR EFFECTS OF COCAETHYLENE AND COCAINE IN RATS
    WANG, YL
    WALKER, LA
    DAVIS, WM
    RESEARCH COMMUNICATIONS IN SUBSTANCES OF ABUSE, 1993, 14 (04) : 217 - 226
  • [6] CARDIOVASCULAR EFFECTS OF COCAINE IN ANESTHETIZED AND CONSCIOUS RATS
    PITTS, DK
    UDOM, CE
    MARWAH, J
    LIFE SCIENCES, 1987, 40 (11) : 1099 - 1111
  • [7] Cross-sensitization of the reinforcing effects of cocaine and amphetamine in rats
    Yu Liu
    Drake Morgan
    David C. S. Roberts
    Psychopharmacology, 2007, 195 : 369 - 375
  • [8] CARDIOVASCULAR SENSITIZATION TO NOREPINEPHRINE AFTER COCAINE
    KAUMANN, AJ
    FERMOSO, JD
    ARAMENDI.A
    ACTA PHYSIOLOGICA LATINOAMERICANA, 1966, 16 (03) : 301 - &
  • [9] Cross-sensitization of the reinforcing effects of cocaine and amphetamine in rats
    Liu, Yu
    Morgan, Drake
    Roberts, David C. S.
    PSYCHOPHARMACOLOGY, 2007, 195 (03) : 369 - 375
  • [10] Single prolonged stress effects on sensitization to cocaine and cocaine self-administration in rats
    Eagle, Andrew L.
    Singh, Robby
    Kohler, Robert J.
    Friedman, Amy L.
    Liebowitz, Chelsea P.
    Galloway, Matthew P.
    Enman, Nicole M.
    Jutkiewicz, Emily M.
    Perrine, Shane A.
    BEHAVIOURAL BRAIN RESEARCH, 2015, 284 : 218 - 224
12345