MYB PROTEIN BINDS TO MULTIPLE SITES IN THE HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 LONG TERMINAL REPEAT AND TRANSACTIVATES LTR-MEDIATED EXPRESSION

被引：43
作者：
BOSSELUT, R
LIM, F
ROMOND, PC
FRAMPTON, J
BRADY, J
GHYSDAEL, J
机构：
[1] EUROPEAN MOLEC BIOL LAB,DIFFERENTIAT PROGRAM,W-6900 HEIDELBERG,GERMANY
[2] NCI,MOLEC VIROL LAB,BETHESDA,MD 20892
来源：
VIROLOGY | 1992年 / 186卷 / 02期
关键词：
D O I：
10.1016/0042-6822(92)90044-P
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The members of the c-myb proto-oncogene family encode sequence-specific transcriptional activators. In T cells, expression of c-myb and the related B-myb gene is induced following mitogenic stimulation. Using a purified recombinant protein, we report here that the human T cell lymphotropic virus type 1 (HTLV-1) LTR contains six specific binding sites for Myb. We also show that HTLV-1 LTR chloramphenicol acetyl transferase reporter plasmids are specifically transactivated by c-Myb. These data suggest a role for members of the Myb family as a link between transcriptional activation of the HTLV-1 LTR and T cell activation events. © 1992.
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页码：764 / 769
页数：6
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