X-RAY STUDIES ON PHOSPHOLIPID-BILAYERS .10. INTERACTIONS WITH CHLORTETRACYCLINE HYDROCHLORIDE

被引：0
|
作者：
SUWALSKY, M
NEIRA, F
SANCHEZ, I
机构：
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 1991年 / 46卷 / 1-2期
关键词：
X-RAY DIFFRACTION; PHOSPHOLIPID BILAYERS; CHLORTETRACYCLINE HYDROCHLORIDE;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study deals with the structural pertubations that the antibiotic chlortetracycline hydrochloride (CTC) can produce on phospholipid bilayers. Two multibilayer systems, one built-up of dimyristoylphosphatidylethanolamine (DMPE) and the other of dimyristoylphosphatidylcholine (DMPC) were allowed to interact with different concentrations of CTC in the absence and presence of water. The study was carried out by X-ray diffraction methods and all experiments were done below the phospholipid main transition temperatures. The results showed that CTC produced significant perturbations on DMPC even in the absence of water, whereas they were much milder in DMPE.
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页码：133 / 138
页数：6
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