INHIBITION OF POTASSIUM-EVOKED RELEASE OF CHOLECYSTOKININ FROM RAT CAUDATE-PUTAMEN, CEREBRAL-CORTEX AND HIPPOCAMPUS INCUBATED INVITRO BY PHENCYCLIDINE AND RELATED-COMPOUNDS

被引：5

作者：

ALLARD, LR

BROG, JS

VIERECK, JC

CONTRERAS, PC

JACOBSON, AE

RICE, KC

BEINFELD, MC

机构：

[1] ST LOUIS UNIV,SCH MED,DEPT PHARMACOL,1402 S GRAND BLVD,ST LOUIS,MO 63104

[2] GD SEARLE,CHESTERFIELD,MO 63198

[3] NIDDKD,MED CHEM LAB,BETHESDA,MD 20892

来源：

BRAIN RESEARCH | 1990年 / 522卷 / 02期

关键词：

Caudate-putamen; Cerebral cortex; Cholecystokinin; Hippocampus; N-methyl-d-aspartate; Phencyclidine;

D O I：

10.1016/0006-8993(90)91464-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Potassium-evoked release of cholecystokinin (CCK) from slices of caudate-putamen, hippocampus, and cerebral cortex was inhibited in a dose-related fashion by phencyclidine (PCP). In order to further examine this effect, PCP-like ligands (dexoxadrol, levoxadrol, PCMP and MK-801) as well as compounds known to interact with the sigma receptor ((+)-SKF, DTG, (+)-3-PPP,n and pentazocine) were tested. While some of these compounds inhibited CCK release, their rank order potency (Dex = Lev > PCP > PCMP > DTG = MK-801 = (+)-3-PPP) differs from that of known PCP-N-methyl-d-aspartate linked effects or sigma interactions. These results suggest that the mechanism by which PCP acts to inhibit CCK release may involve a novel type of PCP interaction. © 1990.

引用

页码：224 / 226

页数：3