Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel

被引：57
作者：
Dirani, Maya [1 ]
Nasreddine, Wassim [2 ]
Abdulla, Fatima [3 ]
Beydoun, Ahmad [2 ]
机构：
[1] Amer Univ Beirut, Med Ctr, Div Pediat Neurol, Beirut, Lebanon
[2] Amer Univ Beirut, Med Ctr, Dept Neurol, Beirut, Lebanon
[3] Salmaniya Med Complex, Dept Clin Neurosci, Manama, Bahrain
来源：
EPILEPSY & BEHAVIOR CASE REPORTS | 2014年 / 2卷
关键词：
Lafora disease; Perampanel; Progressive myoclonic epilepsy; Anticonvulsants;
D O I：
10.1016/j.ebcr.2014.09.003
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Lafora disease is a rare and fatal disease characterized by seizures, progressive cognitive and behavioral deterioration, as well as cerebellar dysfunction. Currently, there is no efficacious treatment that will control the seizures and improve the cognitive decline in this disease. We report a patient with Lafora disease who experienced a dramatic amelioration in her seizure frequency as well as the associated neurological and cognitive dysfunction following initiation of treatment with perampanel administered as monotherapy. Perampanel is the first potentially efficacious treatment for Lafora disease. We discuss a potential mechanism for the efficacy of perampanel in this disease. (C) 2014 The Authors. Published by Elsevier Inc.
引用
收藏
页码：164 / 166
页数：3
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