SYNTHESIS AND SRN1 REACTION OF THE 1ST QUINONE-OXAZOLE BIOREDUCTIVE ALKYLATING AGENT

被引：0

作者：

CROZET, MP

SABUCO, JF

TAMBURLIN, I

BARREAU, M

GIRAUD, L

VANELLE, P

机构：

[1] CTR RECH VITRY ALFORTVILLE,F-94403 VITRY,FRANCE

[2] FAC PHARM MARSEILLE,EYE DIS LAB,F-13385 MARSEILLE 4,FRANCE

来源：

HETEROCYCLES | 1993年 / 36卷 / 01期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(2-Chloromethyloxazol-5-yl)-3,5,6-trimethyl-1,4-benzoquinone, the first compound of a new quinone-heterocyclic class of bioreductive alkylating agent, was prepared from trimethylhydroquinone in 8 steps and reacted by S(RN)1 reaction with lithium salt of 2-nitropropane. The C-alkylation derivative showing its ability to react as one electron bioreductive alkylating agent was obtained in 88% yield.

引用

页码：45 / 54

页数：10

共 19 条

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