An uncertainty metric to evaluate deformation vector fields for dose accumulation in radiotherapy

被引：5

作者：

Takemura, Akihiro ^{[1
]}

Nagano, Akira ^{[2
]}

Kojima, Hironori ^{[3
,5
]}

Ikeda, Tomohiro ^{[4
]}

Yokoyama, Noriomi ^{[5
]}

Tsukamoto, Kosuke ^{[3
]}

Noto, Kimiya ^{[3
]}

Isomura, Naoki ^{[3
]}

Ueda, Shinichi ^{[3
]}

Kawashima, Hiroki ^{[1
]}

机构：

[1] Kanazawa Univ, Fac Hlth Sci, Inst Med Pharmaceut & Hlth Sci, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 9200942, Japan

[2] Okayama Univ Hosp, Div Radiol, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan

[3] Kanazawa Univ Hosp, Dept Radiol Technol, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan

[4] Southern Tohoku Proton Therapy Ctr, Dept Radiat Oncol, 7-115 Yatsuyamada, Koriyama, Fukushima 9638563, Japan

[5] Kanazawa Univ, Grad Sch Med Sci, Div Hlth Sci, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 9200942, Japan

来源：

PHYSICS & IMAGING IN RADIATION ONCOLOGY | 2018年 / 6卷

基金：

日本学术振兴会;

关键词：

Deformable image registration; Uncertainty; Deformation vector field correctness; Radiotherapy;

D O I：

10.1016/j.phro.2018.05.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: In adaptive radiotherapy, deformable image registration (DIR) is used to propagate delineations of tumors and organs into a new therapy plan and to calculate the accumulated total dose. Many DIR accuracy metrics have been proposed. An alternative proposed here could be a local uncertainty (LU) metric for DIR results. Materials and methods: The LU represented the uncertainty of each DIR position and was focused on deformation evaluation in uniformly-dense regions. Four cases demonstrated LU calculations: two head and neck cancer cases, a lung cancer case, and a prostate cancer case. Each underwent two CT examinations for radiotherapy planning. Results: LU maps were calculated from each DIR of the clinical cases. Reduced fat regions had LUs of 4.6 +/- 0.9 mm, 4.8 +/- 1.0 mm, and 4.5 +/- 0.7 mm, while the shrunken left parotid gland had a LU of 4.1 +/- 0.8mm and the shrunken lung tumor had a LU of 3.7 +/- 0.7 mm. The bowels in the pelvic region had a LU of 10.2 +/- 3.7 mm. LU histograms for the cases were similar and 99% of the voxels had a LU < 3 mm. Conclusions: LU is a new uncertainty metric for DIR that was demonstrated for clinical cases. It had a tolerance of < 3 mm.

引用

页码：77 / 82

页数：6