FISH IN GENOME RESEARCH AND MOLECULAR DIAGNOSTICS

被引：26

作者：

VANOMMEN, GJB ^{[1
]}

BREUNING, MH ^{[1
]}

RAAP, AK ^{[1
]}

机构：

[1] LEIDEN UNIV,DEPT CYTOCHEM & CYTOMETRY,2300 RA LEIDEN,NETHERLANDS

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/0959-437X(95)80043-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fluorescence in situ hybridization (FISH) has profoundly altered the aspect of genome research and molecular diagnostics. Deletions of only a few kilobases can be detected by hybridizing probes to naked DNA fibers. Loss or gain of chromosomal material in tumor cells can be visualized using comparative genome hybridization. Further diversification of FISH application will result from new ultrasensitive detection techniques.

引用

页码：304 / 308

页数：5

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