BIOCHEMISTRY OF ALZHEIMERS-DISEASE AMYLOID PLAQUES

被引：36

作者：

FRASER, PE ^{[1
]}

LEVESQUE, L ^{[1
]}

MCLACHLAN, DR ^{[1
]}

机构：

[1] UNIV TORONTO,CTR RES NEURODEGENERAT DIS,TORONTO M5S 1A8,ON,CANADA

来源：

CLINICAL BIOCHEMISTRY | 1993年 / 26卷 / 05期

关键词：

ALZHEIMERS DISEASE; A-BETA PROTEIN; AMYLOID; SENILE PLAQUES; AMYLOID PRECURSOR PROTEIN;

D O I：

10.1016/0009-9120(93)90110-R

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

One of the principal identifying features of Alzheimer's disease (AD) is the extracellular deposition of fibrous protein aggregates in the form of amyloid plaques. The major component of these deposits is the amyloid beta (A beta) protein that is a proteolytic fragment of the integral membrane amyloid precursor protein (APP). Understanding the pathways responsible for A beta formation and the mechanism by which it accumulates within the brain could provide key answers to AD pathogenesis. This review will explore the biochemistry of A beta and its precursor, the possible causal relationship between amyloid and AD-associated neuronal death, the role of additional cellular elements in amyloid formation, and the potential application of these components in clinical diagnosis.

引用

页码：339 / 349

页数：11

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