IDIOPATHIC RECURRING STUPOR - A CASE WITH POSSIBLE INVOLVEMENT OF THE GAMMA-AMINOBUTYRIC-ACID (GABA)ERGIC SYSTEM

被引：30
作者：
TINUPER, P
MONTAGNA, P
CORTELLI, P
AVONI, P
LUGARESI, A
SCHOCH, P
BONETTI, EP
GALLASSI, R
SFORZA, E
LUGARESI, E
机构：
[1] UNIV BOLOGNA,INST NEUROL,I-40126 BOLOGNA,ITALY
[2] F HOFFMANN LA ROCHE & CO LTD,DIV PHARMA,CH-4002 BASEL,SWITZERLAND
来源：
ANNALS OF NEUROLOGY | 1992年 / 31卷 / 05期
关键词：
D O I：
10.1002/ana.410310507
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A patient had recurrent spontaneous episodes of stupor or coma in the absence of toxic, metabolic, or structural brain damage. Ictal electroencephalography showed fast 14 Hz background activity; sleep studies excluded narcolepsy. Flumazenil (Anexate), a benzodiazepine antagonist, promptly resolved the episodes and normalized the electroencephalogram. Radioreceptor binding studies showed the presence of a ligand to the central benzodiazepine receptor in plasma and cerebrospinal fluid during the episodes, suggesting a gamma-aminobutyric acid (GABA)ergic system involvement in the origin of the attacks.
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页码：503 / 506
页数：4
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