DETERMINATION OF WARFARIN IN DRINKING-WATER BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AFTER SOLID-PHASE EXTRACTION

被引：10
作者：
DALBACKE, J
DAHLQUIST, I
PERSSON, C
机构：
[1] Analytical and Quality Development Department, Gacell Laboratories AB, S-201 80 Malmö
来源：
JOURNAL OF CHROMATOGRAPHY | 1990年 / 507卷
关键词：
D O I：
10.1016/S0021-9673(01)84215-1
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A method for the determination of 0.1 μg/l of warfarin in drinking water involving concentration by solid-phase extraction is described. A 1000-ml volume of drinking water is aspirated through a solid-phase extraction column and warfarin is eluted to 1.0 ml. The eluate is analysed by reversed-phase high-performance liquid chromatography with UV detection. The detection limit is 0.02 μg/l. Recoveries of greater than 90% were obtained when tap water was spiked with warfarin. © 1990.
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页码：381 / 387
页数：7
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