REGULATION OF NEUROTENSIN RECEPTOR MESSENGER-RNA EXPRESSION BY THE RECEPTOR ANTAGONIST SR-48692 IN THE RAT MIDBRAIN DOPAMINERGIC-NEURONS

被引：11
|
作者：
YAMADA, M [1 ]
BOLDENWATSON, C [1 ]
WATSON, MA [1 ]
CHO, T [1 ]
COLEMAN, NJ [1 ]
YAMADA, M [1 ]
RICHELSON, E [1 ]
机构：
[1] MAYO CLIN JACKSONVILLE, DEPT PSYCHOL, JACKSONVILLE, FL 32224 USA
来源：
MOLECULAR BRAIN RESEARCH | 1995年 / 33卷 / 02期
关键词：
NEUROTENSIN RECEPTOR; DOPAMINE; SR; 48692; UP-REGULATION; ANTAGONIST; MESSENGER RNA;
D O I：
10.1016/0169-328X(95)00094-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, we demonstrated that the tyrosine hydroxylase-like immune-reactive (possibly dopaminergic) neurons express neurotensin receptor mRNA in the rat substantia nigra and in the ventral tegmental area. Additionally, 2 weeks treatment with the neurotensin receptor antagonist SR 48692 increased mRNA levels in the substantia nigra. These data suggest that neurotensin receptor expression in the perikarya and in the terminal regions of dopaminergic neurons is regulated by its endogenous agonist in vivo.
引用
收藏
页码：343 / 346
页数：4
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