MOLECULAR MODELING OF THE NORRIE DISEASE PROTEIN PREDICTS A CYSTINE KNOT GROWTH-FACTOR TERTIARY STRUCTURE

被引：149

作者：

MEITINGER, T

MEINDL, A

BORK, P

ROST, B

SANDER, C

HAASEMANN, M

MURKEN, J

机构：

[1] EUROPEAN MOLEC BIOL LAB,D-69012 HEIDELBERG,GERMANY

[2] MAX DELBRUCK CTR MOLEC MED,D-13122 BERLIN,GERMANY

[3] INST JACQUES MONOD,F-75251 PARIS,FRANCE

来源：

NATURE GENETICS | 1993年 / 5卷 / 04期

关键词：

D O I：

10.1038/ng1293-376

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The X-lined gene for Norrie disease, which is characterized by blindness, deafness and mental retardation has been cloned recently. This gene has been thought to code for a putative extracellular factor; its predicted amino acid sequence is homologous to the C-terminal domain of diverse extracellular proteins. Sequence pattern searches and three-dimensional modelling now suggest that the Norrie disease protein (NDP) has a tertiary structure similar to that of transforming growth factor beta (TGF beta). Our model identifies NDP as a member of an emerging family of growth factors containing a cystine knot motif, with direct implications for the physiological role of NDP. The model also sheds light on sequence related domains such as the C-terminal domain of mucins and of von Willebrand factor.

引用

页码：376 / 380

页数：5

共 42 条

[1]

Sporn M.B., Roberts A.B., Peptide growth factors and their receptors, (1990)

[2]

McDonald N.Q., Hendrickson W.A., A structural superfamily of growth factors containing a cystine knot motif, Cell, 73, pp. 421-424, (1993)

[3]

Angeletti R.H., Bradshaw R.A., Nerve growth factor from mouse submaxillary gland: Amino acid sequence, Proc. natn. Acad. Sci. U. S. A, 68, pp. 2417-2420, (1971)

[4]

McDonald N.Q., New protein fold revealed by a 2, 3-Å resolution crystal structure of nerve growth factor, Nature, 364, pp. 411-414, (1991)

[5]

Schlunegger M.P., Grutter M.G., An unusual feature revealed by the crystal structure at 2, 2Å resolution of human transforming growth factor-β2, Nature, 358, pp. 430-434, (1992)

[6]

Daopin S., Piez K.A., Ogawa Y., Davies D.R., Crystal structure of transforming growth factor β2: An unusual fold for the superfamily, Science, 257, pp. 369-373, (1992)

[7]

Oefner C., D'Arcy A., Winkler F.K., Eggiman B., Hosang M., Crystal structure of human platelet-derived growth factor BB, EMBO J, 11, pp. 3921-3926, (1992)

[8]

Swindells M.B., Daopin S., Cohen G.H., Davies D., Structural similarity between transforming growth factor. β2 and nerve growth factor, Science, 258, pp. 1160-1162, (1992)

[9]

Lin L.-F.H., GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons, Science, 260, pp. 1130-1132, (1993)

[10]

Meindl A., Norrie disease is caused by mutations in an extracellular protein resembling C-terminal globular domain of mucins, Nature Genet, 2, pp. 139-143, (1992)

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