THE COMPLEMENT CONTROL PROTEIN HOMOLOG OF HERPESVIRUS SAIMIRI REGULATES SERUM COMPLEMENT BY INHIBITING C3 CONVERTASE ACTIVITY

被引：70

作者：

FODOR, WL ^{[1
]}

ROLLINS, SA ^{[1
]}

BIANCOCARON, S ^{[1
]}

ROTHER, RP ^{[1
]}

GUILMETTE, ER ^{[1
]}

BURTON, WV ^{[1
]}

ALBRECHT, JC ^{[1
]}

FLECKENSTEIN, B ^{[1
]}

SQUINTO, SP ^{[1
]}

机构：

[1] UNIV ERLANGEN NURNBERG,INST KLIN & MOLEK VIROL,D-91054 ERLANGEN,GERMANY

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 06期

关键词：

D O I：

10.1128/JVI.69.6.3889-3892.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The herpesvirus saimiri genome encodes a complement control protein homolog (CCPH). Stable mammalian cell transfectants expressing a recombinant transmembrane form of CCPH (mCCPH) or a 5'FLAG epitope-tagged mCCPH (5'FLAGmCCPH) conferred resistance to complement-mediated cell damage by inhibiting the lytic activity of human serum complement. The function of CCPH was further defined by showing that the mCCPH and the 5'FLAGmCCPH transfectants inhibited, C3 convertase activity and effectively reduced cell surface deposition of the activated complement component, C3d.

引用

页码：3889 / 3892

页数：4

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