PHARMACOKINETICS OF MIDAZOLAM IN CHILDREN - COMPARATIVE-STUDY OF INTRANASAL AND INTRAVENOUS ADMINISTRATION

被引：109

作者：

REY, E ^{[1
]}

DELAUNAY, L ^{[1
]}

PONS, G ^{[1
]}

MURAT, I ^{[1
]}

RICHARD, MO ^{[1
]}

SAINTMAURICE, C ^{[1
]}

OLIVE, G ^{[1
]}

机构：

[1] HOP ST VINCENT DE PAUL,DEPT ANESTHESIOL,F-75674 PARIS 14,FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 41卷 / 04期

关键词：

MIDAZOLAM; PHARMACOKINETICS; INTRANASAL; INTRAVENOUS; CHILDREN; BIOAVAILABILITY;

D O I：

10.1007/BF00314967

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Twelve children 1-5 y old were randomly assigned to receive midazolam 0.2 mg.kg-1 either by the intravenous (IV) or intranasal (IN) routes. After IN administration the rapid onset of absorption was observed (t(max) 12 min). After both routes of administration the half-life was similar (2.2 h IN and 2.4 h IV). After IN administration the apparent plasma clearance and volume of distribution were about twice as high as after IV administration. The results are consistent with an estimated mean bioavailability of 55%.

引用

页码：355 / 357

页数：3

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