ADMINISTRATION OF GROWTH-HORMONE TO PIGS ALTERS THE RELATIVE AMOUNT OF INSULIN-LIKE GROWTH FACTOR-I MESSENGER-RNA IN LIVER AND SKELETAL-MUSCLE

被引:61
作者
GRANT, AL
HELFERICH, WG
KRAMER, SA
MERKEL, RA
BERGEN, WG
机构
[1] MICHIGAN STATE UNIV,DEPT ANIM SCI,GROWTH BIOL PROGRAM,E LANSING,MI 48824
[2] MICHIGAN STATE UNIV,DEPT FOOD SCI & HUMAN NUTR,E LANSING,MI 48824
关键词
D O I
10.1677/joe.0.1300331
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The relative amount of insulin-like growth factor-I (IGF-I) mRNA was determined in the liver and skeletal muscle of market weight crossbred barrows (castrated male pigs) using a solution hybridization-nuclease protection assay. Pigs were given either 50-mu-g recombinant porcine GH per kg body weight or vehicle daily for 24 days i.m. They were fed corn-soybean meal diets containing either 140 or 200 g crude protein/kg (low or high protein). The percentage of muscle in the carcasses of pigs given GH was greater (P < 0.01) than that of controls. Relative to controls, GH increased (P < 0.05) the amount of liver IGF-I mRNA by 2.7-fold in pigs fed the low protein diet and 3.0-fold in pigs fed the high protein diet. The amount of IGF-I mRNA in the muscles of GH-treated pigs was 77% and 84% of control pigs in those fed the low and high protein diets respectively (P < 0.08). GH increased (P < 0.001) the serum concentration of IGF-I 1.6-fold in pigs fed the low protein diet and 2.0-fold in those fed the high protein diet. These results indicate that the administration of GH to pigs influences the relative amount of liver IGF-I mRNA. The increased amount of liver IGF-I mRNA and the increased serum IGF-I concentrations suggest that IGF-I plays an endocrine role in mediating GH-induced muscle hypertrophy in pigs.
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页码:331 / &
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