aza-Michael Addition of Primary Amines by Lipases and Microwave Irradiation: A Green Protocol for the Synthesis of Propanenitrile Derivatives

被引：6

作者：

Kerber Araujo, Yara Jaqueline ^{[1
]}

Meleiro Porto, Andre Luiz ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim Sao Carlos, Lab Quim Organ & Biocatalise, Av Joao Dagnone,1100 Ed Quim Ambiental, BR-13563120 Sao Paulo, SP, Brazil

来源：

CURRENT MICROWAVE CHEMISTRY | 2014年 / 1卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Acrylonitrile; amines; biocatalysis; Candida antarctica; catalysts; lipases; michael addition; microwave irradiation; nitriles; orbital shaker; solvent; water;

D O I：

10.2174/2213335601666140610201546

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study aza-Michael addition reactions were used as a Green chemistry protocol to synthesize propanenitrile derivatives. The reactions were performed in both presence and absence of lipases, under orbital shaking and microwave irradiation, using water as a protic solvent and hexane as an aprotic solvent. aza-Michael adducts were synthesized with acceptable yields, under microwave irradiation and water as solvent in the presence of lipase from Candida antarctica in a very short period of time (30 s). The study shows that lipases can be used as a microwave reactor to significantly reduce the reaction time so that yields similar to those of orbital shaking can be obtained.

引用

页码：87 / 93

页数：7

共 51 条

[1] Synthesis of a novel crown ether derived from chiro-inositol and its catalytic activity on the asymmetric Michael addition [J].