Predominant Dissemination of PVL-Negative CC89 MRSA with SCCmec Type II in Children with Impetigo in Japan

被引：21

作者：

Kikuta, H. ^{[1
]}

Shibata, M. ^{[2
]}

Nakata, S. ^{[3
]}

Yamanaka, T. ^{[4
]}

Sakata, H. ^{[5
]}

Akizawa, K. ^{[6
]}

Kobayashi, K. ^{[7
]}

机构：

[1] Touei Hosp, Pediatr Clin, Higashi Ku, N 41,E 16, Sapporo, Hokkaido 0070841, Japan

[2] Hlth Sci Univ Hokkaido, Dept Pediat, Kita Ku, Sapporo, Hokkaido 0028072, Japan

[3] Nakata Pediat Clin, Shiroishi Ku, Sapporo, Hokkaido 0030023, Japan

[4] Yamanaka Tatsuru Pediat, Shiroishi Ku, Sapporo, Hokkaido 0030022, Japan

[5] Asahikawa Kosei Hosp, Dept Pediat, Asahikawa, Hokkaido 0788211, Japan

[6] Hokkaido Univ, Med Hosp, Dept Lab Med, Kita Ku, Sapporo, Hokkaido 0600814, Japan

[7] Sapporo Hokuyu Hosp, Dept Pediat, Shiroishi Ku, Sapporo, Hokkaido 0030006, Japan

来源：

INTERNATIONAL JOURNAL OF PEDIATRICS | 2011年 / 2011卷

关键词：

D O I：

10.1155/2011/143872

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background. The ratio of CA-MRSA in children with impetigo has been increasing in Japan. Methods. Antimicrobial susceptibilities of 136 S. aureus isolates from children with impetigo were studied. Furthermore, molecular epidemiological analysis and virulence gene analysis were performed. Results. Of the 136 S. aureus isolates, 122 (89.7%) were MSSA and 14 (10.3%) were MRSA. Of the 14 MRSA strains, 11 belonged to CC89 (ST89, ST91, and ST2117) and carried diverse types of SCCmec: type II (IIb: 3 strains; unknown subtype: 4 strains), type IVa (2 strains), and unknown type (2 strains). The remaining three strains exhibited CC8 (ST-8)-SCCmec type VIa, CC121 (ST121)-SCCmec type V, and CC5 (ST5)-nontypeable SCCmec element, respectively. None were lukS-PV-lukF-PV gene positive. Gentamicin-and clarithromycin-resistant strains were frequently found in both MRSA and MSSA. Conclusions. PVL-negative CC89-SCCmec type II strains are the most predominant strains among the CA-MRSA strains circulating in the community in Japan.

引用

页数：8

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