ENDOTHELIN-1 EXPRESSION BY HUMAN HEPATOCELLULAR-CARCINOMA

被引：17

作者：

KAR, S

YOUSEM, SA

CARR, BI

机构：

[1] UNIV PITTSBURGH,SCH MED,PITTSBURGH TRANSPLANT INST,PITTSBURGH,PA 15260

[2] UNIV PITTSBURGH,SCH MED,DEPT PATHOL,PITTSBURGH,PA 15260

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 216卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.2652

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasma levels of endothelin-1 (ET-1) are markedly higher in patients with hepatocellular carcinoma (HCC) than in normal controls. In order to further investigate this, we evaluated ET-1 immunoreactivity and mRNA expression in human HCC tissue. 70% (14/20) of the tumor tissues immunostained positively with ET-1 antibody and a significant association was observed between immunostaining in cells lining the tumor feeding vessels and tumor vascularity as determined by hepatic angiography. Moreover, the neoplastic hepatocytes in the tumors also stained positively with ET-1 antibody. All of the HCC tissue samples which immunostained for ET-1 also expressed ET-1 mRNA, indicating that ET-1 is actively synthesized by the tumors. (C) 1995 Academic Press, Inc.

引用

页码：514 / 519

页数：6

共 25 条

[1]

Bagnato A, 1995, CLIN CANCER RES, V1, P1059

[2] ANALYSIS OF ENDOTHELIN-1-INDUCED CONTRACTIONS OF GUINEA-PIG TRACHEA, PULMONARY VEINS AND DIFFERENT TYPES OF PULMONARY-ARTERIES [J].