A NEW VARIANT OF INTERACTION BETWEEN PHOSPHOLIPID ANTIBODIES AND THE PROTEIN-C SYSTEM

被引：63

作者：

BOKAREWA, MI ^{[1
]}

BLOMBACK, M ^{[1
]}

EGBERG, N ^{[1
]}

ROSEN, S ^{[1
]}

机构：

[1] CHROMOGENIX AB, MOLNDAL, SWEDEN

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 1994年 / 5卷 / 01期

关键词：

PHOSPHOLIPID ANTIBODIES; PROTEIN C; LUPUS ANTICOAGULANT;

D O I：

10.1097/00001721-199402000-00006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The influence of 38 IgG fractions with either cardiolipin antibodies only (CLa) or both CLa and lupus anticoagulant activity (LA) on the response to activated protein C (APC) and on the snake venom activation of protein C were investigated. Five of eight IgG fractions with LA activity showed a tendency to reduce the effect of APC in the aPTT method and to simulate the APC-resistance phenomenon. This effect was not observed in IgG fractions without LA activity. The addition of IgG fractions did not decrease enzymatic activation of protein C in normal plasma. No correlation was found between sample protein C activity and CLa level or the extent of clotting time prolongation. These observations suggested that acquired resistance to APC in the presence of some types of phospholipid antibodies may be a cause of thrombophilia in such patients.

引用

页码：37 / 41

页数：5

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