THE LONG-TERM OBSERVATION OF THE TRANSPLANTATION OF ENCAPSULATED RAT ISLETS TO THE DIABETIC MICE

被引：2
作者：
SHU, CD
HE, J
机构：
[1] Artificial Cells Research Lab, First Affiliated Hospital of Chongqing University of Medical Sciences Chongqing
来源：
BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY | 1993年 / 21卷 / 01期
关键词：
IMMUNO-ISOLATED MEMBRANE; ISLET TRANSPLANTATION; XENOTRANSPLANTATION;
D O I：
10.3109/10731199309118299
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Rat islets encapsulated in the immuno-isolated membrane were transplanted intraperitoneally into 11 streptozotocin induced diabetic mice. The effective rate was 91% while all rejected in the 11 nonencapsulated xenograft group. 4 mice showed complete remission and longest normoglycemic period in those mice was 360 days. The pathological changes of islets of the long-term succesful xenograft group were studied and showed atrophy. It proved that the immuno-isolated membrane can protect rejection during xeno-transplantation.
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页码：85 / 89
页数：5
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